WebbPossible roles of a tumor suppressor gene PIG11 in hepatocarcinogenesis and As2O3-induced apoptosis in liver cancer cells. J ... BACKGROUND: Our previous studies demonstrated that p53-induced gene 11 (PIG11) was involved in arsenic trioxide (As(2)O(3))-induced apoptosis in human gastric cancer MGC-803 cells. Here, we studied … WebbExplanation: In normal cells, p53 functions as a "guardian of the genome" by monitoring DNA damage and promoting either DNA repair or apoptosis (programmed cell death) depending on the severity of the damage. The functions of p53 are tightly regulated, and its activation or inactivation is critical for normal cell cycle progression.

Analysis of the p53 gene mutations in patients with multiple …

Webb23 jan. 2004 · Based upon these studies, p53 came to be classified as a tumor antigen. These observations were the first clue to the mechanism of how the SV40 tumor antigen … p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of … bristly pincushion

Tumour suppressor protein molecular model F006 / 9450

Webb25 jan. 2006 · Abstract: The tumor suppressor p53 is a phosphoprotein barely detectable in the nucleus of normal cells. Upon cellular stress, particularly that induced by DNA … Webb22 jan. 2024 · The tumor suppressor gene TP53 and its downstream genes P21 and MDM2 play crucial roles in combating DNA damage at the G 1 /S cell cycle checkpoint. Polymorphisms in these genes can lead to the development of various diseases. Webb14 dec. 1990 · Abstract. Mutations of the gene encoding p53, a 53-kilodalton cellular protein, are found frequently in human tumor cells, suggesting a crucial role for this gene … bristly personality