Plk4 cancer
Webb1 jan. 2024 · PLK4 regulates multiple cellular biological processes and is implicated in tumorigenesis. Dysregulation of PLK4 leads to a predisposition towards cancer … Webb1 sep. 2014 · Mice heterozygous for Plk4 develop spontaneous cancers of the liver and lung. 21 In keeping with this predisposition, Plk4 +/− murine embryonic fibroblasts …
Plk4 cancer
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WebbUncontrolled proliferation is one of the hallmarks of cancer. In this study, we analyzed the expression of the cell cycle-related genes receptor for hyaluronan (HA)-mediated motility … Webb15 juli 2013 · The Plk4 binding regions of Cep192 and Cep152 (residues 190–240 and 1–46, respectively) are rich in negatively charged amino acids, suggesting that Plk4 localization to centrioles depends on electrostatic interactions with the positively charged polo-box domain.
WebbPLK4. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … WebbRole of polo-like kinase 4 (PLK4) in epithelial cancers and recent progress in its small molecule targeting for cancer management Role of polo-like kinase 4 (PLK4) in epithelial …
Webb18 juli 2024 · A series of studies indicated that PLK4 promoted the progression of cancers. PLK4 was prevailing high expressed in the breast cancer, with only 2.6% samples being … Webb18 mars 2024 · Conclusions We show that by targeting a centrosome regulator, PLK4, to activate the cytosolic DNA sensing-mediated immune response, CFI-400945 effectively restrained tumor progression through cell cycle inhibition and inducing antitumor immunity to achieve a durable suppressive effect even in late-stage mouse HCC. CONFLICT OF …
WebbPLK4 overexpressed in colorectal cancer and gastric cancer, while had low-expression levels in hepatocellular carcinoma. Some reports has demonstrated that PLK4 is highly expressed in breast cancer tissues or cells [ 28 , 29 ], but the role of PLK4 in breast cancer has not been thoroughly elucidated.
Webb15 jan. 2024 · The polo family serine threonine kinase Plk4 has been proposed as a therapeutic target in advanced cancers based on increased expression in primary … jet tub steam shower comboWebbBackground: Our study aimed to investigate the association of polo-like kinase 4 (PLK4) expression with tumor features as well as survival in non-small cell lung cancer (NSCLC) … jet turbines build a boatWebb1 apr. 2024 · The important role of PLK4 in centrosome biology coupled with its demonstrated connection with cancer development and progression signaling provides … jet turbine build a boatWebb24 nov. 2024 · Although the role of PLK4 has been studied in several cancers (37)(38) (39) (40), to narrow our scope for this review, we have focused on epithelial cancers. Although PLK4 has not been found to be ... jet turbine applications for carsWebb9 sep. 2024 · CFI-400945 is a PLK4 inhibitor that also targets aurora B, and is in clinical trials as a therapeutic agent for patients with breast cancer 20,21,22. We therefore tested the effect of CFI-400945 ... jet tub switch replacementWebb24 maj 2024 · Polo-like kinase 4 (PLK4), a vital regulator of centriole duplication, is important for maintaining genome stability. Dysregulation of PLK4 has been found in several human cancers and is associated with a predisposition to tumorigenesis. Herein, we describe the discovery of (E)-4-(3-arylvinyl-1H-indazol-6-yl)pyrimi jet tuner how to improve throttle responceWebb1 dec. 2015 · 2.1. Elevated Plk4 expression dramatically advances the onset of tumour formation in p53-deficient mice. Centrosome amplification has been identified as a marker of poor prognosis of aggressive, drug-resistant tumours in breast, pancreatic and colorectal cancer patients [43,44], but the relationship of centriole amplification to … jett wallpaper download