Web30 ago 2011 · Theoretically, both shLAIR-1 and hLAIR-2 are able to block the interaction between cell-expressed hLAIR-1 and collagen, thereby functioning as a receptor antagonist . We recently found that recombinant LAIR-2–Fc is an efficient inhibitor of the interaction between platelets and collagen, whereas LAIR-1–Fc is not. WebThe protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced …
Purified Mouse Anti-Human LAIR-1 (CD305) - BD Biosciences
Web18 feb 2010 · Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), one of the most widely spread immune receptors, attenuates immune cell activation when bound to … WebhLAIR-1 DX26 IgG1 mAb (14 g/ml in 50 l of PBS) or anti–hLAIR-2 1A7 IgG1 mAb (12 g/ml in 50 l of PBS). Three washes were performed with 150 l of PBS. After washing, the plates were incubated for 2 hours at room tem-perature with PBS supplemented with 3% BSA to block non-specific interactions. Meanwhile, the biologic samples (urine, plasma, or cookies cache löschen
Cancer immunotherapy based on blocking immune suppression mediated by ...
WebThus, LAIR-1 binds a common collagen motif in a hydroxyproline-dependent manner. hLAIR-1-IgG bound less effi ciently to (GPO) 10 peptide as compared with collagen, suggesting that apart from the ... Web14 giu 2024 · In humanized mouse tumor models, NC410 reduces tumor growth that is dependent on T cells. Immunohistochemical analysis of human tumors shows that NC410 binds to collagen-rich areas where LAIR-1 + immune cells are localized. Our findings show that NC410 might be a novel strategy for cancer immunotherapy for immune-excluded … Web19 lug 2007 · Rick Flair video montage cookies by the dozen near me