WebApr 12, 2024 · Circular RNAs (circRNAs) are a newly discovered class of endogenously expressed non-coding RNAs (ncRNAs). They are highly stable, covalently closed molecules that frequently exhibit tissue-specific expression in eukaryotes. A small number of circRNAs are abundant and have been remarkably conserved throughout evolution. Numerous … WebCircular RNAs (circRNAs), a new class of ncRNAs, were first discovered in the 1970s. 13 In the past, they were thought to be a byproduct of splicing errors, with no biological function. 14 However, with the wide application of high-throughput sequencing technology and bioinformatic methods, high levels of circRNA have been detected in tissues ...
Emerging roles of non-coding RNAs in endothelial cell …
WebMar 16, 2024 · Introduction. Circular RNAs (circRNAs) are an emerging class of endogenous RNAs abundantly expressed in eukaryotic cells.These molecules are generated from precursor mRNAs through non-canonical splicing and are widely expressed in diverse species.circRNAs include exonic circRNAs, exon-intron circRNAs (EIciRNAs), … WebDiabetes is characterized by changed homeostasis of blood glucose levels, which is associated with various complications, including cardiomyopathy, atherosclerosis, endothelial dysfunction, nephropathy, retinopathy and neuropathy.In recent years, accumulative evidence has demonstrated that circular RNAs are identified as a novel … sphe 8368
The biogenesis, biology and characterization of circular RNAs
WebAug 15, 2024 · As a novel class of endogenous RNAs, circRNAs, have a covalently closed continuous loop, with neither a 5’to 3’polarity, nor a polyadenylated tail. Numerous … WebHowever, the mechanism of most circular RNAs and their clinical application values in human cancers remain unknown, including in colorectal cancer (CRC). Methods: In this study, we focused on the expression pattern and clinical values of hsa_circ_0000711 in CRC. The expression level of hsa_circ_0000711 in 101 paired CRC tissues and 3 CRC … WebFigure 1: Diagram depicting the roles and mechanisms of circRNAs in cancers. circRNAs = circular RNAs, miRNA = microRNA. Due to limited length of this review, some crucial … sphe8368ulc